Obesity paradox in heart failure: a heavy matter
نویسندگان
چکیده
Obesity and heart failure are two of the leading causes of morbidity and mortality in the world. The relationship between obesity and cardiovascular diseases is complex and not fully understood. While the risk of developing heart failure has been shown to be higher in patients who are obese, there is a survival advantage for obese and overweight patients compared with normal weight or low weight patients. This phenomenon was first described by Horwich et al. and was subsequently confirmed in other large trials. The advantage exists irrespective of the type, aetiology, or stage of heart failure. Patients with morbid obesity (body mass index >40 kg/m2), however, do not have the same survival advantage of their obese counterparts. There are several alternative indices of obesity available that may be more accurate than body mass index. The role of weight loss in patients with heart failure is unclear; thus, providing sound clinical advice to patients remains difficult. Future prospective trials designed to evaluate the link between obesity and heart failure will help us understand more fully this complex relationship.
منابع مشابه
Impact of obesity and the obesity paradox on prevalence and prognosis in heart failure.
Obesity has reached epidemic proportions in the United States and worldwide. Considering the adverse effects of obesity on left ventricular (LV) structure, diastolic and systolic function, and other risk factors for heart failure (HF), including hypertension and coronary heart disease, HF incidence and prevalence, not surprisingly, is markedly increased in obese patients. Nevertheless, as with ...
متن کاملConcerning the Role of Gender Difference in Obesity Paradox in Patients With Heart Failure.
(CVD) risk factors, CV structure and function, and increases the prevalence of most CVD, including coronary heart disease (CHD) and heart failure (HF) (2,3). Nevertheless, we reported an obesity paradox in 6 studies of 22,807 patients with HF (4); a metaanalysis of 89 studies in 1.3 million patients with established CHD which confirmed a strong obesity paradox (5); and a meta-analysis by Flegal...
متن کاملObesity Paradox in the Course of Cerebrovascular Diseases.
Obesity remains an important risk factor of cardiovascular and cerebrovascular diseases. However, it has been observed that increased body fat and body mass index predicted longer survival after the occurrence of a cardiovascular event. This observation has been named the obesity paradox. Initially, the term obesity paradox referred to the observation of the better outcome of cardiovascular dis...
متن کاملObesity and mortality: summary of best evidence with explanations for the obesity paradox
The link between obesity and increased risk of mortality is well established. However, those who are obese have greater survival when they have chronic diseases such as rheumatoid arthritis or cardiac failure; this is known as the ‘‘obesity paradox’’. The obesity paradox is most probably attributable to obese individuals being more susceptible to milder forms of disease than normal-weight indiv...
متن کاملSelection bias: A missing factor in the Obesity Paradox debate
The September issue of Obesity featured articles by Tobias and Hu (1) and Flegal and Kalantar-Zadeh (2) that explored the observation that, in clinical populations, such as individuals with heart failure, chronic kidney disease, or diabetes, those with higher BMI often have lower mortality rates than leaner individuals. The articles disagree whether this phenomenon, known as the obesity paradox...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2016